backgroundworker - The Best Way to Handle Big File Uploads in Azure -

We are hosting a VM our web application, where users upload large files to their profiles - in fact they 3D models are - Web APIs of Web API

What I am working on is to find a way to efficiently manage these long-running uploading jobs / processes in place of this VM, where I am hosting the application.

I know there are some blue ways but I want to make it right. Which is the most effective way to do this? Worker role, a web page can run for a script to store it in the queue or to upload to web jobs?

File uploading function is also doing some other processes like generating thumbnails, accumulating SQL and etc.